This issue of the Charcot Foundation Bulletin invites us to take a dual look at the history of neurology and multiple sclerosis. 

On the bicentennial of the birth of Jean-Martin Charcot, the first to describe multiple sclerosis as a distinct clinical entity, we revisit his complex legacy. As the founder of modern neurology, he contributed to the advancement of medicine through observation and scientific rigor, but his work also fits into a context that today raises questions about our practices and ethics. 

In the same spirit, we offer a historical overview of multiple sclerosis treatments. From the first empirical attempts to today's highly specialized therapies, the progress made has been considerable. These advances remind us how much each step forward depends on the accumulation of knowledge, the commitment of researchers, and the constant support of the community. 

Finally, this Bulletin also marks an important milestone for our Foundation: the official launch of our new website, a veritable center of knowledge on multiple sclerosis. Designed as an evolution of the original site, it has been redesigned, enriched, and updated to continue to offer a reliable, clear, and accessible reference for everyone—patients, families, caregivers, and researchers. 

Looking back helps us to better understand the present and prepare for the future. For nearly forty years, the Charcot Foundation has worked tirelessly to support research. In a context where public funding is becoming scarce and confidence in science is sometimes being tested, your generosity makes all the difference. 

Thanks to you, we can continue to believe and work towards a future where multiple sclerosis is no longer a death sentence. 

Prof. Dr. Bénédicte Dubois President of the Charcot Foundation, defeating multiple sclerosis