Scientific
publications

It is imperative that the results of both basic and clinical research be published to inform the medical and neurological scientific community. Even if some results are negative, it is important to make them known in order to shed light on future options and to trigger creative discussions on the reasons for any failure. This is both necessary and an ethical imperative in the dissemination of knowledge and in the long march towards increasing the effectiveness of treatments for a disease that remains incurable to this day.

‍Prof. Em. Dr Christian Sindic
President

2025

Van Vegel L, Voets AM, Vanmierlo T, Schreiber R.

Insights from an academic endeavor into central nervous system drug discovery

Jun 2025

Neural Regeneration Research

Van Veggel L, Scheppers M, Tiane A, … Hellings N, Schreiber R, Vanmierlo T.

EAAT3 modulation: A potential novel avenue towards remyelination in multiple sclerosis

May 2025

Biomedicine & Pharmacotherapy

De Bondt M, … Baeten P, Broux B, Gouwy M, Matthys P, Hellings N, Struyf S.

Effect on neutrophil migration and antimicrobial functions by the Bruton's tyrosine kinase inhibitors tolebrutinib, evobrutinib, and fenebrutinib

Mar 2025

Journal of Leukocyte Biology

Van Broeckhoven J, Mussen F, Schepers M, Vanmierlo T, Hellings N.

A new player in the game: identification of C1ql1 as a novel factor driving OPC differentiation

Jan 2025

The FEBS Journal

2024

Van den Bos J, … El Ouaamari Y, Wens I, Cools N.

The efficiency of Brain-Derived Neurotrophic Factor Secretion by mRNA-electroporated regulatory T cells is highly impacted by their activation status

Dec 2024

European Journal of Immunology

Hermans D, Hellings N, Broux B.

Oncostatin M: a love-hate relationship in neuroinflammation

Dec 2024

Neural regeneration research

Santinelli FB, Veldkamp R,… Feys P.

Hemodynamics of the Frontopolar and Dorsolateral Pre-Frontal Cortex in People with Multiple Sclerosis During Walking, Cognitive Subtraction, and Cognitive-Motor Dual-Task

Dec 2024

Neurorehabilitation and Neural repair

Stölting A, Vanden Bulcke C,Borreli S, Bugli C, Du Pasquier R, van Pesch V, Maggi P.

Clinical relevance of paramagnetic rim lesion heterogeneity in multiple sclerosis

Dec 2024

Annals of clinical and translational Neurology

Bernaerts E, … Mathys P, Vandooren J.

Human monocyte-derived macrophages shift subcellular metalloprotease activity depending on their activation state

Nov 2024

iScience

Loix M, Vanherle s, Turri M, Kemp S, Fernandes KJL, Hendriks JJA, Bogie JFJ.

Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders

Nov 2024

Molecular Neurodegeneration

Mwema A, Gratpain V,… Perdaens O, van Pesch V, Muccioli GG, des Rieux A.

Impact of calcitriol and PGD2-G-loaded lipid nanocapsules on oligodendrocyte progenitor cell differentiation and remyelination

Nov 2024

Drug Delivery and translational research

Van de Waterweg Berends A, Broux B, Machiels B, Gillet L, Hellings N.

The EBV-MS connection: the enigma remains

Aug 2024

Frontiers in Immunology

Borrelli S, Martire MS, Stölting A, … Maggi P.

Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis

Jul 2024

Neurology, Neuroimmunology & Neuroinflammation

Van Delen M, Derdelinckx J, Wouters K, Nelissen I, Cools N.

A systematic review and meta-analysis of clinical trials assessing safety and efficacy of human extracellular vesicle-based therapy

Jul 2024

Journal of extracellular vesicles

Veeckmans G, Van San E, Vanden Berghe T.

A guide to ferroptosis, the biological rust of cellular membranes

Jul 2024

FEBS Journal

Akbarian F, Rossi C, Costers L, D’hooghe MB, D’haeseleer M, Nagels G, Van Schependom J.

Jun 2024

Multiple Sclerosis Journal

Labrak Y, Alhouayek M, Mwema A,… van Pesch V, Muccioli GG, des Rieux A.

The combined administration of LNC-encapsulated retinoic acid and calcitriol stimulates oligodendrocyte progenitor cell differentiation in vitro and in vivo after intranasal administration

Jun 2024

International Journal of Pharmaceutics

Leenders F, Koole L, Slaets H, Tiane A, van den Hove D, Vanmierlo T.

Navigating oligodendrocyte precursor cell aging in brain health

Jun 2024

Mechanisms of ageing and development

Bachmann H, Vandemoortele B, Vermeissen V, Carrette E, Vonck K, Boon P, Raedt R, Laureys G.

Vagus nerve stimulation enhances remyelination and decreases innate neuroinflammation in lysolecithin-induced demyelination

May 2024

Brain Stimulation

Baeten P, Hamad I, Hoeks C, …, Heilings N, Broux B.

Rapamycin rescues loss of function in blood-brain barrier-interacting Tregs

Apr 2024

Journal of Clinical Investigation Insight

Van Veggel L, … Schreiber R, Heitman LH, Vanmierlo T.

Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays

Apr 2024

ACS Chemical Neurosciences

Gratpain V, Loriot A, Bottemanne P, … van Pesch V, Muccioli GG, des Rieux A.

Influence of a pro-inflammatory stimulus on the miRNA and lipid content of human dental stem cell-derived extracellular vesicles and their impact on microglial activation

Mar 2024

Helyon

Tiane A, Somers V, Hellings N, van den Hove DLA, Vanmierlo T.

The impact of sample storage on blood methylation: towards assessing myelin gene methylation as a biomarker for progressive multiple sclerosis.

Mar 2024

International Journal of Molecular Sciences

Vanden Bulcke C, Stölting A, Maric D, Macq B, Absinta M, Maggi P.

Comparative overview of multi-shell diffusion MRI models to characterize the microstructure of multiple sclerosis lesions and periplaques

Mar 2024

NeuroImage: Clinical

De Keersmaecker AV, … Willekens B.

A metformin add-on clinical study in multiple sclerosis to evaluate brain remyelination and neurodegeneration (MACSiMiSE-BRAIN): study protocol for a multi-center randomized placebo controlled clinical trial

Feb 2024

Frontiers in Immunology

Beckers L, Baeten P, … Kleinewietfeld M, Broux B, Fraussen J, Somers V.

Alterations in the innate and adaptive immune system in a real-world cohort of multiple sclerosis patients treated with ocrelizumab

Feb 2024

Clinical Immunology

Perdaens O, Bottemanne P, van Pesch V.

MicroRNAs dysregulated in multiple sclerosis affect the differentiation of CG-4 cells, an oligodendrocyte progenitor cell line

Feb 2024

Frontiers in Cellular Neuroscience

Perdaens O, van Pesch V.

MicroRNAs are dysregulated in peripheral blood mononuclear cells in multiple sclerosis and correlate with T cell mediators

Jan 2024

Journal of Neuroimmunology

2023

Hosseinkhani B, … Vanmierlo T, Michiels L, Hellings N, Broux B.

Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood - brain barrier function

Dec 2023

Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood-brain barrier function

Mwema A., Muccioli GG, des Rieux A.

Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis

Dec 2023

Journal of Controlled Release

Corrales AVG, Verberk SGS, Haidar M, … Hendriks JJA.

Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination

Sep 2023

Proceedings of the National Academy of Sciences

Van Horebeek L, David M, Dedoncker N, Mallants K, BijnensB, Goris A, Dubois B.

A targeted sequencing extension for transcript genotyping in single-cell transcriptomics

Sep 2023

Life Science Alliance

Van San E,… van Loo G,… Vandenabeele P,… Vanden Berghe T.

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

Sep 2023

Cell Death & Differentiation

Hermans D, Rodriguez-Mogeda C, Kemps H, Bronckaers A, de Vries HE, Broux B.

Nectins and Nectin-like molecules drive vascular development and barrier function

Aug 2023

Angiogenesis

Tiane A, Schepers M, … Hellings N, van den Hove D, Vanmierlo T.

From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions

Aug 2023

Acta Neuropathologica

Grajchen E, Loix M, Baeten P, …. Broux B, Kleinewietfeld M, Hendriks JJA, Bogie JFJ.

Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

Jun 2023

Cellular & Molecular Immunology

Schepers M, Malheiro A, Gamardo AS, Hellings N,….Vanmierlo T, Wieringa P.

Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model

Jun 2023

European Journal of Pharmaceutical Sciences

Pegoretti V, … Houben E, Broux B, Hellings N,… Eisel ULM.

Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS

May 2023

Journal of Neuroinflammation

Van Loo G, Bertrand MJM.

Death by TNF: a road to inflammation

May 2023

Nature Reviews Immunology

Akbarian F, Rossi C, Costers L, D’hooghe MB, D’haeseleer M, Nagels G, Van Schependom J.

The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis

Mar 2023

Human Brain Mapping

Balcaen T., Piens C., Mwema A., … Des Rieux, A., … Kerckhofs G.

Revealing the three-dimensional murine brain microstructure by contrast-enhanced computed tomography

Mar 2023

Frontiers in Neuroscience

Beckers L., Somers V., Fraussen J.

IgD-CD27- double negative (DN) B cells: Origins and functions in health and disease

Mar 2023

Immunology Letters

Hermans D, van Beers L, Broux B.

Nectin Family Ligands Trigger Immune Effector Functions in Health and Autoimmunity

Mar 2023

Biology

Schepers M, Paes D, Tiane A, … Baeten P, Broux B, …Heilings N, Vanmierlo T.

Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis

Mar 2023

Brain Behavior and Immunity

El Ouaamari Y, Van den Bosch J, Willekens B, Cools N, Wens I.

Neurotrophic Factors as Regenerative Therapy for Neurodegenerative Diseases: Current Status, Challenges and Future Perspectives

Feb 2023

International Journal of Molecular Sciences

Mwema A., Bottemanne P.,… Alhouayek M., Muccioli GG., des Rieux A.

Lipid nanocapsules for the nose-to-brain delivery of the anti-inflammatory bioactive lipid PGD2-G

Feb 2023

Nanomedicine

Burgelman M., Dujardin P., Vandendriessche C., Vandenbroucke RE.

Free complement and complement containing extracellular vesicles as potential biomarkers for neuroinflammatory and neurodegenerative disorders

Jan 2023

Frontiers in Immunology

McNamara NB, … Bogie JFJ, … Hendriks JJA, … Miron VE

Microglia regulate central nervous system myelin growth and integrity

Jan 2023

Nature

2022

Van Horebeek L, Dedoncker N, Dubois B, Goris A.

Frequent somatic mosaicism in T lymphocyte subsets in individuals with and without multiple sclerosis

Dec 2022

Frontiers in Immunology

Verreycken J., Baeten P., Broux B.

Regulatory T cell therapy for multiple sclerosis: Breaching (blood-brain) barriers

Dec 2022

Human Vaccines & Immunotherapeutics

Haidar, M., Loix M., …Bogie JFJ., Hendriks, JJA.

Targeting lipophagy in macrophages improves repair in multiple sclerosis

Nov 2022

Autophagy

Vogel I., … Goriely S., Leo D., Moser M.

Agonistic anti-CD27 antibody ameliorates EAE by suppressing IL-17 production

Oct 2022

European Journal of Immunology

Meena M., … Berneman Z., Watts R., Cools N.

A Microfluidic In Vitro Three-Dimensional Dynamic Model of the Blood-Brain Barrier to Study the Transmigration of Immune Cells

Sep 2022

Brain Sciences

Goris A.,Vandebergh M.,McCauley JL.,Saarela J., Cotsapas C.

Genetics of multiple sclerosis: lessons from polygenicity

Sep 2022

Lancet Neurology

Hermans D., Houben E., Baeten P., …Fraussen J.,…Hellings N., Broux B.

Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity

Aug 2022

Acta Neuropathologica

Hoeks C., Duran G., Hellings N., Broux B.

When Helpers Go Above and Beyond: Development and Characterization of Cytotoxic CD4+ T Cells

Jul 2022

Frontiers in Immunology

Brocke S., Epstein P.M., Nelson R., Vanmierlo T.

Editorial: Cyclic Nucleotide Phosphodiesterases (PDEs) in Immune Regulation and Inflammation

Jul 2022

Frontiers in Pharmacology

Janssens I., ..., Van den Bos J., ..., Berneman Z.N., Wens I., Cools N.

Engineering of regulatory cells by means of mRNA electroporation in a GMP-compliant manner.

Jun 2022

Cytotherapy

Hassanabadi NS., Broux B., Marinivic S., Gotthardt D.

Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis

Jun 2022

Frontiers in Immunology

Van Broeckhoven J., …Ponsaerts P.

Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury

Apr 2022

Journal of Neuroinflammation

Labrak Y., … Muccioli GG., des Rieux A.

Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells

Apr 2022

International Journal of Pharmaceutics

Beliën J., Goris A., Matthys P.

Natural Killer Cells in Multiple Sclerosis: Entering the Stage

Apr 2022

Frontiers in Immunology

Baeten P., Van Zeebroeck L., Kleinewietfeld M., Hellings N., Broux B.

Improving the Efficacy of Regulatory T Cell Therapy

Apr 2022

Clinical Reviews in Allergy & Immunology

Vandebergh M. Dubois B., Goris A.

Effects of Vitamin D and Body Mass Index on Disease Risk and Relapse Hazard in Multiple Sclerosis: A Mendelian Randomization Study

Apr 2022

Neurology, Neuroimmunolology & Neuroinflammation

Vandebergh M., … Dubois B., Goris A.

Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study

Mar 2022

Frontiers in Immunology

Van Breedam E., Berneman ZW., … Vanden Berghe T., … Ponsaerts P.

Luminescent Human iPSC-Derived Neurospheroids Enable Modeling of Neurotoxicity After Oxygen-glucose Deprivation

Mar 2022

Neurotherapeutics

Van den Bos J.,… Coolsz N., Wens I.

Are Cell-Based Therapies Safe and Effective in the Treatment of Neurodegenerative Diseases? A Systematic Review with Meta-Analysis

Feb 2022

Biomolecules

Van Coillie S., …Vandenabeele P., Vanden Berghe T.

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Feb 2022

Nature Communications

Guns J., Vanherle S., Hendriks JJA., Bogie JFJ.

Protein Lipidation by Palmitate Controls Macrophage Function

Feb 2022

Cells

2021

Vandooren J. and Itoh I.

Alpha-2-Macroglobulin in Inflammation, Immunity and Infections

Dec 2021

Frontiers in Immunology

Liston A., Humblet-Baron S., Duffy D., Goris A.

Human immune diversity: from evolution to modernity

Dec 2021

Nature Immunology

Cauwels A. et al.

Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE

Nov 2021

Nature.communications/scientific reports

Bogie JFJ., Vanmierlo T., … Hendriks JJA.

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner

Nov 2021

Journal of Autoimmunity

Tiane A. Schepers M.,… Hellings N., …Vanmierlo T.

DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation

Oct 2021

Cellular and Molecular Life Sciences

Meena M., … De Laere M.,… Benerman Z., Cools N.

Transmigration across a Steady-State Blood-Brain Barrie Induces Activation of Circulating Dendritic Cells Partly Mediated by Actin Cytoskeletal Reorganization

Sep 2021

Membranes

Hassannia B., Van Coillie S., Vanden Berghe T.

Ferroptosis: Biological Rust of Lipid Membranes

Aug 2021

Antioxidants & Redox Signaling

Garcia Corales A.V., Haidar M., Bogie J.F.J., Hendriks J.J.A.

Fatty Acid Synthesis in Glial Cells of the CNS

Jul 2021

International Journal of Molecular Sciences

Wens I., Janssens I., Derdelinckx., Meena M., Willekens B., Cools N.

Made to Measure: Patient-Tailored Treatment of Multiple Sclerosis Using Cell-Based Therapies

Jul 2021

International Journal of Molecular Sciences

Quarta A., Benerman ZW., Ponsaerts P.

Functional consequences of a close encounter between microglia and brain-infiltrating monocytes during CNS pathology and repair

Jul 2021

Journal of Leukocytes Biology

Gratpain, V., … Muccioli GG., van Pesch V., des Rieux A.

Extracellular vesicles for the treatment of central nervous system diseases

Jul 2021

Advanced Drug Delivery Reviews

Bottemanne P., … Alhouayek M., Muccioli GG.

N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice

Jul 2021

Neurotherapeutics

Vandooren J. … Opdenakker G.

Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases

Jun 2021

Frontiers in Immunology

Vandebergh M., … Dubois B., Goris A.

Genetic Variation in WNT9B Increases Relapse Hazard in Multiple Sclerosis

May 2021

Annals of Neurology

Smets I., … Dubois B., Matthys P., Liston A., Goris A.

Treatment-Induced BAFF Expression and B Cell Biology in Multiple Sclerosis

May 2021

Frontiers in Immunology

Oltean T., … Vanden Berghe T., … Vandenabeele P.

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

May 2021

Cell Death and Disease

Costers L., Van Schependom J., … De Tiège X., Goldman S., D’haeseleer M., D’hooghe MB., … Nagels G.

The role of hippocampal theta oscillations in working memory impairment in multiple sclerosis

Apr 2021

Human Brain Mapping

Van Schependom J., … D’hooghe MB., D’haeseleer M., … De Tiège X., Goldman S., …Nagels G.

Increased brain atrophy and lesion load is associated with stronger lower alpha MEG power in multiple sclerosis patients

Mar 2021

Neuroimage: Clinical

Quarta A…Le Blon D.,…Ponsaerts P.

Murine induced pluripotent stem cell-derived neuroimmune cell culture models emphasize opposite immune-effector functions of interleukin 13-primed microglia and macrophages in terms of neuroimmune toxicity

Feb 2021

Glia

Smets I., Goris A., … Dubois B.

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients

Jan 2021

Nature Communications / Scientific report

Peters M., … Hellings N., … Ethirajan A.

PEGylating poly(p-phenylene vinylene)-based bioimaging nanoprobes

Jan 2021

Journal of colloid and interface science

Ciccone L., Vandooren J., Nencetti S., Orlandini E.

Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's Disease

Jan 2021

Pharmaceuticals

2020

Derdelinckx J. …Willekens B., Cras P., Benerman ZN., Cools N.

HLA Class II Genotype Does Not Affect the Myelin Responsiveness of Multiple Sclerosis Patients

Dec 2020

Cells

Jacobs W., …Vanden Berghe T., Jorens PG.

Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID-19): autopsy reveals a ferroptosis signature

Dec 2020

ESC Heart Failure

Baeten P., Hellings N., Broux B.

In vitro tailoring of regulatory T cells prior to cell therapy

Nov 2020

Trends in Molecular Medicine

Wiernicki B., … Vandenabeele P., … Vanden Berghe T.

Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

Oct 2020

Cell Death and Disease

Roggeri A., … Tiane A., Hellings N., … Vanmierlo T.

Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation

Oct 2020

International Journal of Molecular sciences

Orefice NS., … Muccioli GG.

miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions

Sep 2020

eLife

Bogie JFJ., Grajchen E., … Broux B., Stinissen P., … Hendriks JJA.

CNS delivery of anti-CD52 antibodies modestly reduces disease severity in an animal model for multiple sclerosis

Aug 2020

Therapeutic Advances in Chronic Disease

Serifova X., Ugarte-Berzal E., Opdenakker G., Vandooren J.

Homotrimeric MMP-9 is an active hitchhiker on alpha-2-macroglobulin partially escaping protease inhibition and internalization through LRP-1

Aug 2020

Cellular and Molecular Life Sciences

Quarta A., Berneman Z., Ponsaerts P.

Neuroprotective modulation of microglia effector functions following priming with interleukin 4 and 13: current limitations in understanding their mode-of-action

Aug 2020

Brain, Behavior and Immunity

Grajchen E.,… Hendricks JJA., Bogie JFJ.

CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation

Jul 2020

Journal of Neuroinflammation

Vanmierlo T., van Horssen J., Hellings N., Broux B.

Editorial: Neuro-Immune Connections to Enable Repair in CNS Disorders

Jul 2020

Frontiers in Immunology

Van Horebeek L., Goris A.

Transcript-specific regulation in T-cells in multiple sclerosis susceptibility

Jul 2020

European Journal of Human Genetics

Holgado A. …Afonina IS., Beyaert R.

Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors

Jul 2020

Frontiers in Immunology

Costers L., Van Schependom J., ….De Tiège X., Goldman S., D’haeseleer M., D’hooghe MB., …Nagels G.

Spatiotemporal and spectral dynamics of multi-item working memory as revealed by the n-back task using MEG

Jun 2020

Human Brain Mapping

Opdenakker G., El-Asrar AA., Van Damme J.

Remnant Epitopes Generating Autoimmunity: From Model to Useful Paradigm

May 2020

Remnant epitopes generating autoimmunity: from model to useful paradigm

Bogie JFJ., Grajchen E., … Hendriks JJA.

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

May 2020

Journal of Experimental Medicine

Oldoni E., … Van Horebeek L.,… Dubois B., Goris A.

CHIT1 at Diagnosis Reflects Long-Term Multiple Sclerosis Disease Activity

Apr 2020

Annals of Neurology

Martens A., … Voet;s., …Lamkanfi M., … van Loo G.

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Apr 2020

Nature Immunology

Boon L., Ugarte-Berzal E., Vandooren J., Opdenakker G.

Protease propeptide structures, mechanisms of activation, and functions

Apr 2020

Critical Reviews in Biochemistry and Molecular Biology

Houben E. ..Vanmierlo T.,..Opdenaker G,....Broux B.,…Hellings N.

Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination

Mar 2020

Proceedings of the National Academy of Sciences

Perdaens O.,… van Pesch V.

CSF microRNAs discriminate MS activity and share similarity to other neuroinflammatory disorders

Feb 2020

Neurology

Bogie JFJ., Haidar M., Kooij G., Hendriks JJA.

Fatty acid metabolism in the progression and resolution of CNS disorders

Jan 2020

Advanced Drug Delivery Reviews

2019

Quarta A., Le Blon D.,…Ponsaerts P.

Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation

Nov 2019

Brain, Behavior and Immunity

Van Schependom J., …D’hooghe MB., D’haeseleer M., …De Tiège X., Goldman S., …Nagels G.

Altered transient brain dynamics in multiple sclerosis: Treatment or pathology?

Nov 2019

Human Brain Mapping

Tiane A., … Hellings N., … Vanmierlo T.

From OPC to Oligodendrocyte: An Epigenetic Journey

Oct 2019

Cells

Fraussen J., … Somers V.

Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD-CD27- Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients

Sep 2019

Journal of Immunology

Derdelinckx J…. Cools N.

Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Aug 2019

Journal of Neuroinflammation

Rybakin V., … Vandooren J, … Opdenakker G.

Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity

Aug 2019

Biochemical Journa

Schepers M., Tiane A., … , Piccart E., …Hellings N., …Vanmierlo T.

Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment

Jul 2019

Frontiers in Immunology

Lloyd AF., … des Rieux A., … Miron VE.

Central nervous system regeneration is driven by microglia necroptosis and repopulation

Jul 2019

Nature Neurosciences

Voet S., Srinivasan S., Lamkanfi M., van Loo G.

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Jun 2019

Embo Molecular Medicine

Hassannia B., Vandenabeele P., Vanden Berghe T.

Targeting Ferroptosis to Iron Out Cancer

Jun 2019

Cancer cell

Van Horebeek L…. Dubois B., Goris A.

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease

Apr 2019

Human Molecular Genetics

Ugarte-Berzal E., Boon L., …Vandooren J., …Opdenakker G.

MMP-9/Gelatinase B Degrades Immune Complexes in Systemic Lupus Erythematosus

Mar 2019

Frontiers in Immunology

Boon L., Ugarte-Berzal E.,…Vandooren J., …Opdenakker G.

Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B

Mar 2019

FEBS Journal

Voet S., Prinz M., van Loo G.

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

Feb 2019

Trends Molecular Medicine

Van Horebeek L., Dubois B., Goris A.

Somatic Variants: New Kids on the Block in Human Immunogenetics

Jan 2019

Trends in Genetics

Vanden Berghe T. and E. Hoste.

Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids

Jan 2019

Cell Death & Differentiation

2018

De Laere M., Derdelinckx J., …Grajchen E., Hendriks JJA, Bogie JFJ.

The physiology of foamy phagocytes in multiple sclerosis

Nov 2018

Acta Neuropathologica Communications

Uyttenhove C., … Van Snick J., … van Pesch V.

Prophylactic treatment against GM-CSF, but not IL-17, abolishes relapses in a chronic murine model of multiple sclerosis

Nov 2018

European Journal of Immunology

Hilven K., … Goris A., Dubois B.

Genetic basis for relapse rate in multiple sclerosis: Association with LRP2 genetic variation

Nov 2018

Multiple Sclerosis Journal

Lagou V.,… Van Horebeek L.,… Dubois B.,… Goris A.

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators

Oct 2018

Cell Reports

Ugarte-Berzal E., … Vandooren J.,… Opdenakker G.

Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis

Oct 2018

PLoS ONE

Taj SH., Le Blon D., …Quarta A.,…Ponsaerts P., Hoehn M.

Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

Jun 2018

Journal of Neuroinflammation

Vandooren J. … Opdenakker G.

Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase

May 2018

Frontiers in Immunology

Voet S., … Lamkanfi M., … van Loo G.

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

May 2018

Nature Communications

Maatveva O., Bogie JFJ., Hendriks JJA., … Kleinewietfeld M.

Western lifestyle and immunopathology of multiple sclerosis

Apr 2018

Annals of New York Academy of Sciences

Smets I., … Dubois B., … Goris A., Sawcer S.

Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells

Mar 2018

Brain

De Laere M., Berneman ZW., Cools N.

To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis

Mar 2018

Journal of Neuropathology and Experimental Neurology

De Laere M., Derdelinckx J., … Cools N.

Shuttling tolerogenic dendritic cells across the BBB in vitro via the introduction of de novo C-C chemokine receptor 5 expression using messenger RNA electroporation

Jan 2018

Frontiers in Immunology

2017

Ravanidis S., Bogie JFJ., … Hendriks JJA., Stinissen P., … Hellings N.

Crosstalk with inflammatory macrophages shapes the regulatory properties of Multipotent Adult Progenitor Cells

Jul 2017

Stem Cells International

De Laere M., … Berneman ZW., Cools N.

Increased Transendothelial Transport of CCL3 Is Insufficient to Drive Immune Cell Transmigration through the Blood-Brain Barrier under Inflammatory Conditions In Vitro

May 2017

Mediators of inflammation

Bogie, JFJ, … Grajchen E., … Hellings N., … Vanmierlo T., Hendriks JJA.

Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes

Mar 2017

Nature communications/scientific reports

Muls N., …Sindic CJM., van Pesch V.

IL-22, GM-CSF and IL-17 in peripheral CD4+ T cell subpopulations during multiple sclerosis relapses and remission. Impact of corticosteroid therapy

Mar 2017

PLoS One

2016

Claes N., Fraussen J., … Hellings N., … Somers V.

Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients

Dec 2016

Journal of Immunology

Zielinska KA., … Opdenakker G., … Van den Steen PE.

Endothelial response to Glucocorticoids in inflammatory diseases

Dec 2016

Frontiers in Immunology

Guglielmetti C., Le Blon D., … Ponsaerts P.

Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Dec 2016

Glia

Fraussen J., Claes N.,…Stinissen P., … Somers V.

B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses

Dec 2016

Clinical Immunology

Le Blon D., … Berneman ZW., Ponsaerts P.

Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Nov 2016

Journal of Neuroinflammation

Gerwien H., … Opdenakker G., … Sorokin L.

Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier

Nov 2016

Science Translational Medicine

Opdenaker G. et al.

Microbiomic and Posttranslational Modifications as Preludes to Autoimmune Diseases

Sep 2016

Trends Molecular Medicine

Lee WP., Willekens B., Cras P., …Berneman ZW., Cools N.

Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens

Sep 2016

Journal of Immunology Research

Gounko NV., Martens E., Opdenakker G., Rybakin V.

Thymocyte development in the absence of matrix metalloproteinase-9/gelatinase B

Jul 2016

Nature Scientific Reports

Gonsette R., Debouverie M., Sindic CJM., Ferré JC., Edan G.

Pixantrone: a B-cell-depleting immunosuppressant for multiple sclerosis patients with active disease

May 2016

Multiple Sclerosis

Dooley J. … Dubois B., Liston A., Goris A.

Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations

May 2016

Neurology, Neuroimmunology & Neuroinflammation

2015

Hilven K., Patsoupolos NA., Dubois B., Goris A.

Burden of risk variants correlates with phenotype of multiple sclerosis

Nov 2015

Multiple Sclerosis Journal

Muls N., … Sindic CJM., van Pesch V.

Regulation of Treg-associated CD39 in multiple sclerosis and effects of corticotherapy during relapse

Oct 2015

Multiple Sclerosis Journal

Deckx N., Wens I., … Cools N.

Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis

Oct 2015

Mediators of inflammation

Ravanidis S., Bogie JFJ., … Stinissen P., … Hellings N.

Neuroinflammatory signals enhance the immunomodulatory and neuroprotective properties of multipotent adult progenitor cells

Sep 2015

Stem Cell Research & Therapy

Goris A.,…Dubois B., Harbo HF.

Genetic variants are major determinants of CSF antibody levels in multiple sclerosis

Mar 2015

Brain

Broux B., … Somers V., … Stinissen P., Hellings N.

IL-15 amplifies the pathogenic properties of CD4+CD28- T cells in multiple sclerosis

Mar 2015

Journal of Immunology