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Disseminating knowledge to shed a light on future options

It is imperative that the results of both basic and clinical research be published to inform the medical and neurological scientific community. Even if some results are negative, it is important to make them known in order to shed light on future options and to trigger creative discussions on the reasons for any failure. This is both necessary and an ethical imperative in the dissemination of knowledge and in the long march towards increasing the effectiveness of treatments for a disease that remains incurable to this day.

‍Prof. Em. Dr Christian Sindic
President

2025

Van Vegel L, Voets AM, Vanmierlo T, Schreiber R.
Insights from an academic endeavor into central nervous system drug discovery
Jun.
2025
Neural Regeneration Research

2024

De Keersmaecker AV, … Willekens B.
A metformin add-on clinical study in multiple sclerosis to evaluate brain remyelination and neurodegeneration (MACSiMiSE-BRAIN): study protocol for a multi-center randomized placebo controlled clinical trial
Feb.
2024
Frontiers in Immunology
Leenders F, Koole L, Slaets H, Tiane A, van den Hove D, Vanmierlo T.
Navigating oligodendrocyte precursor cell aging in brain health
Jun.
2024
Mechanisms of ageing and development
*Loix M, Vanherle s, Turri M, Kemp S, Fernandes KJL, Hendriks JJA, Bogie JFJ.
Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders
Nov.
2024
Molecular Neurodegeneration
Tiane A, Somers V, Hellings N, van den Hove DLA, Vanmierlo T.
The impact of sample storage on blood methylation: towards assessing myelin gene methylation as a biomarker for progressive multiple sclerosis.
Mar.
2024
International Journal of Molecular Sciences
Bachmann H, Vandemoortele B, Vermeissen V, Carrette E, Vonck K, Boon P, Raedt R, Laureys G.
Vagus nerve stimulation enhances remyelination and decreases innate neuroinflammation in lysolecithin-induced demyelination
May
2024
Brain Stimulation
*Gratpain V, Loriot A, Bottemanne P, … van Pesch V, Muccioli GG, des Rieux A.
Influence of a pro-inflammatory stimulus on the miRNA and lipid content of human dental stem cell-derived extracellular vesicles and their impact on microglial activation
Mar.
2024
Helyon
Perdaens O, van Pesch V.
MicroRNAs are dysregulated in peripheral blood mononuclear cells in multiple sclerosis and correlate with T cell mediators
Jan.
2024
Journal of Neuroimmunology
*Van Broeckhoven J, Mussen F, Schepers M, Vanmierlo T, Hellings N.
A new player in the game: identification of C1ql1 as a novel factor driving OPC differentiation
Nov.
2024
The FEBS Journal
Perdaens O, Bottemanne P, van Pesch V.
MicroRNAs dysregulated in multiple sclerosis affect the differentiation of CG-4 cells, an oligodendrocyte progenitor cell line
Feb.
2024
Frontiers in Cellular Neuroscience
Borrelli S, Martire MS, Stölting A, … Maggi P.
Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis
May
2024
Neurology, Neuroimmunology & Neuroinflammation
Santinelli FB, Veldkamp R,… Feys P.
Hemodynamics of the Frontopolar and Dorsolateral Pre-Frontal Cortex in People with Multiple Sclerosis During Walking, Cognitive Subtraction, and Cognitive-Motor Dual-Task
Dec.
2024
Neurorehabilitation and Neural repair
Veeckmans G, Van San E, Vanden Berghe T.
A guide to ferroptosis, the biological rust of cellular membranes
Jul.
2024
FEBS Journal
*Labrak Y, Alhouayek M, Mwema A,… van Pesch V, Muccioli GG, des Rieux A.
The combined administration of LNC-encapsulated retinoic acid and calcitriol stimulates oligodendrocyte progenitor cell differentiation in vitro and in vivo after intranasal administration
Jun.
2024
International Journal of Pharmaceutics
Van de Waterweg Berends A, Broux B, Machiels B, Gillet L, Hellings N.
The EBV-MS connection: the enigma remains
Aug.
2024
Frontiers in Immunology
Vanden Bulcke C, Stölting A, Maric D, Macq B, Absinta M, Maggi P.
Comparative overview of multi-shell diffusion MRI models to characterize the microstructure of multiple sclerosis lesions and periplaques
Mar.
2024
NeuroImage: Clinical
Van Veggel L, … Schreiber R, Heitman LH, Vanmierlo T.
Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays
Apr.
2024
ACS Chemical Neurosciences
Akbarian F, Rossi C, Costers L, D’hooghe MB, D’haeseleer M, Nagels G, Van Schependom J.
Stimulus-related modulation in the 1/f spectral slope suggests an impaired inhibition during a working memory task in people with multiple sclerosis
Jun.
2024
Multiple Sclerosis Journal
Mwema A, Gratpain V,… Perdaens O, van Pesch V, Muccioli GG, des Rieux A.
Impact of calcitriol and PGD2-G-loaded lipid nanocapsules on oligodendrocyte progenitor cell differentiation and remyelination
Nov.
2024
Drug Delivery and translational research
*De Bondt M, … Baeten P, Broux B, Gouwy M, Matthys P, Hellings N, Struyf S.
Effect on neutrophil migration and antimicrobial functions by the Bruton's tyrosine kinase inhibitors tolebrutinib, evobrutinib, and fenebrutinib
Jul.
2024
Journal of Leukocyte Biology
Hermans D, Hellings N, Broux B.
Oncostatin M: a love-hate relationship in neuroinflammation
Dec.
2024
Neural regeneration research
*Stölting A, Vanden Bulcke C,Borreli S, Bugli C, Du Pasquier R, van Pesch V, Maggi P.
Clinical relevance of paramagnetic rim lesion heterogeneity in multiple sclerosis
Oct.
2024
Annals of clinical and translational Neurology
Beckers L, Baeten P, … Kleinewietfeld M, Broux B, Fraussen J, Somers V.
Alterations in the innate and adaptive immune system in a real-world cohort of multiple sclerosis patients treated with ocrelizumab
Feb.
2024
Clinical Immunology
Baeten P, Hamad I, Hoeks C, …, Heilings N, Broux B.
Rapamycin rescues loss of function in blood-brain barrier-interacting Tregs
Apr.
2024
Journal of Clinical Investigation Insight
Van Delen M, Derdelinckx J, Wouters K, Nelissen I, Cools N.
A systematic review and meta-analysis of clinical trials assessing safety and efficacy of human extracellular vesicle-based therapy
Jul.
2024
Journal of extracellular vesicles

2023

Hermans D, Rodriguez-Mogeda C, Kemps H, Bronckaers A, de Vries HE, Broux B.
Nectins and Nectin-like molecules drive vascular development and barrier function
Aug.
2023
Angiogenesis
Tiane A, Schepers M, … Hellings N, van den Hove D, Vanmierlo T.
From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions
Aug.
2023
Acta Neuropathologica
Mwema A., Muccioli GG, des Rieux A.
Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis
Dec.
2023
Journal of Controlled Release
Van Horebeek L, David M, Dedoncker N, Mallants K, BijnensB, Goris A, Dubois B.
A targeted sequencing extension for transcript genotyping in single-cell transcriptomics
Sep.
2023
Life Science Alliance
Grajchen E, Loix M, Baeten P, …. Broux B, Kleinewietfeld M, Hendriks JJA, Bogie JFJ.
Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity
Jun.
2023
Cellular & Molecular Immunology
Burgelman M., Dujardin P., Vandendriessche C., Vandenbroucke RE.
Free complement and complement containing extracellular vesicles as potential biomarkers for neuroinflammatory and neurodegenerative disorders
Jan.
2023
Frontiers in Immunology
McNamara NB, … Bogie JFJ, … Hendriks JJA, … Miron VE
Microglia regulate central nervous system myelin growth and integrity
Jan.
2023
Nature
Mwema A., Bottemanne P.,… Alhouayek M., Muccioli GG., des Rieux A.
Lipid nanocapsules for the nose-to-brain delivery of the anti-inflammatory bioactive lipid PGD2-G
Feb.
2023
Nanomedicine
Van Loo G, Bertrand MJM.
Death by TNF: a road to inflammation
May
2023
Nature Reviews Immunology
Hosseinkhani B, … Vanmierlo T, Michiels L, Hellings N, Broux B.
Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood - brain barrier function
Dec.
2023
Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood-brain barrier function
Beckers L., Somers V., Fraussen J.
IgD-CD27- double negative (DN) B cells: Origins and functions in health and disease
Mar.
2023
Immunology Letters
Akbarian F, Rossi C, Costers L, D’hooghe MB, D’haeseleer M, Nagels G, Van Schependom J.
The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis
Mar.
2023
Human Brain Mapping
Corrales AVG, Verberk SGS, Haidar M, … Hendriks JJA.
Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination
Sep.
2023
Proceedings of the National Academy of Sciences
Balcaen T., Piens C., Mwema A., … Des Rieux, A., … Kerckhofs G.
Revealing the three-dimensional murine brain microstructure by contrast-enhanced computed tomography
Mar.
2023
Frontiers in Neuroscience
Van San E,… van Loo G,… Vandenabeele P,… Vanden Berghe T.
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression
Sep.
2023
Cell Death & Differentiation
Schepers M, Malheiro A, Gamardo AS, Hellings N,….Vanmierlo T, Wieringa P.
Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model
Jun.
2023
European Journal of Pharmaceutical Sciences
Pegoretti V, … Houben E, Broux B, Hellings N,… Eisel ULM.
Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS
May
2023
Journal of Neuroinflammation
Schepers M, Paes D, Tiane A, … Baeten P, Broux B, …Heilings N, Vanmierlo T.
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis
Mar.
2023
Brain Behavior and Immunity
Hermans D, van Beers L, Broux B.
Nectin Family Ligands Trigger Immune Effector Functions in Health and Autoimmunity
Mar.
2023
Biology
El Ouaamari Y, Van den Bosch J, Willekens B, Cools N, Wens I.
Neurotrophic Factors as Regenerative Therapy for Neurodegenerative Diseases: Current Status, Challenges and Future Perspectives
Feb.
2023
International Journal of Molecular Sciences

2022

Goris A.,Vandebergh M.,McCauley JL.,Saarela J., Cotsapas C.
Genetics of multiple sclerosis: lessons from polygenicity
Sep.
2022
Lancet Neurology
Hoeks C., Duran G., Hellings N., Broux B.
When Helpers Go Above and Beyond: Development and Characterization of Cytotoxic CD4+ T Cells
Jul.
2022
Frontiers in Immunology
Guns J., Vanherle S., Hendriks JJA., Bogie JFJ.
Protein Lipidation by Palmitate Controls Macrophage Function
Feb.
2022
Cells
Janssens I., ..., Van den Bos J., ..., Berneman Z.N., Wens I., Cools N.
Engineering of regulatory cells by means of mRNA electroporation in a GMP-compliant manner.
Jun.
2022
Cytotherapy
Brocke S., Epstein P.M., Nelson R., Vanmierlo T.
Editorial: Cyclic Nucleotide Phosphodiesterases (PDEs) in Immune Regulation and Inflammation
Jul.
2022
Frontiers in Pharmacology
Haidar, M., Loix M., …Bogie JFJ., Hendriks, JJA.
Targeting lipophagy in macrophages improves repair in multiple sclerosis
Nov.
2022
Autophagy
Van Horebeek L, Dedoncker N, Dubois B, Goris A.
Frequent somatic mosaicism in T lymphocyte subsets in individuals with and without multiple sclerosis
Dec.
2022
Frontiers in Immunology
Hermans D., Houben E., Baeten P., …Fraussen J.,…Hellings N., Broux B.
Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity
Aug.
2022
Acta Neuropathologica
Beliën J., Goris A., Matthys P.
Natural Killer Cells in Multiple Sclerosis: Entering the Stage
Apr.
2022
Frontiers in Immunology
Van den Bos J.,… Coolsz N., Wens I.
Are Cell-Based Therapies Safe and Effective in the Treatment of Neurodegenerative Diseases? A Systematic Review with Meta-Analysis
2022
Biomolecules
Vandebergh M., … Dubois B., Goris A.
Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study
Mar.
2022
Frontiers in Immunology
Meena M., … Berneman Z., Watts R., Cools N.
A Microfluidic In Vitro Three-Dimensional Dynamic Model of the Blood-Brain Barrier to Study the Transmigration of Immune Cells
Sep.
2022
Brain Sciences
Van Broeckhoven J., …Ponsaerts P.
Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury
Apr.
2022
Journal of Neuroinflammation
Van Coillie S., …Vandenabeele P., Vanden Berghe T.
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
Feb.
2022
Nature Communications
Baeten P., Van Zeebroeck L., Kleinewietfeld M., Hellings N., Broux B.
Improving the Efficacy of Regulatory T Cell Therapy
Apr.
2022
Clinical Reviews in Allergy & Immunology
Labrak Y., … Muccioli GG., des Rieux A.
Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells
Apr.
2022
International Journal of Pharmaceutics
Vandebergh M. Dubois B., Goris A.
Effects of Vitamin D and Body Mass Index on Disease Risk and Relapse Hazard in Multiple Sclerosis: A Mendelian Randomization Study
Apr.
2022
Neurology, Neuroimmunolology & Neuroinflammation
Hassanabadi NS., Broux B., Marinivic S., Gotthardt D.
Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis
Jun.
2022
Frontiers in Immunology
Van Breedam E., Berneman ZW., … Vanden Berghe T., … Ponsaerts P.
Luminescent Human iPSC-Derived Neurospheroids Enable Modeling of Neurotoxicity After Oxygen-glucose Deprivation
Mar.
2022
Neurotherapeutics
Verreycken J., Baeten P., Broux B.
Regulatory T cell therapy for multiple sclerosis: Breaching (blood-brain) barriers
Dec.
2022
Human Vaccines & Immunotherapeutics
Vogel I., … Goriely S., Leo D., Moser M.
Agonistic anti-CD27 antibody ameliorates EAE by suppressing IL-17 production
Oct.
2022
European Journal of Immunology

2021

Bogie JFJ., Vanmierlo T., … Hendriks JJA.
Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
Nov.
2021
Journal of Autoimmunity
Costers L., Van Schependom J., … De Tiège X., Goldman S., D’haeseleer M., D’hooghe MB., … Nagels G.
The role of hippocampal theta oscillations in working memory impairment in multiple sclerosis
Apr.
2021
Human Brain Mapping
Meena M., … De Laere M.,… Benerman Z., Cools N.
Transmigration across a Steady-State Blood-Brain Barrie Induces Activation of Circulating Dendritic Cells Partly Mediated by Actin Cytoskeletal Reorganization
Sep.
2021
Membranes
Van Schependom J., … D’hooghe MB., D’haeseleer M., … De Tiège X., Goldman S., …Nagels G.
Increased brain atrophy and lesion load is associated with stronger lower alpha MEG power in multiple sclerosis patients
Mar.
2021
Neuroimage: Clinical
Gratpain, V., … Muccioli GG., van Pesch V., des Rieux A.
Extracellular vesicles for the treatment of central nervous system diseases
Jul.
2021
Advanced Drug Delivery Reviews
Hassannia B., Van Coillie S., Vanden Berghe T.
Ferroptosis: Biological Rust of Lipid Membranes
Aug.
2021
Antioxidants & Redox Signaling
Oltean T., … Vanden Berghe T., … Vandenabeele P.
Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL
May
2021
Cell Death and Disease
Smets I., Goris A., … Dubois B.
Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients
Jan.
2021
Nature Communications / Scientific report
Cauwels A. et al.
Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE
Nov.
2021
Nature.communications/scientific reports
Quarta A…Le Blon D.,…Ponsaerts P.
Murine induced pluripotent stem cell-derived neuroimmune cell culture models emphasize opposite immune-effector functions of interleukin 13-primed microglia and macrophages in terms of neuroimmune toxicity
Feb.
2021
Glia
Vandebergh M., … Dubois B., Goris A.
Genetic Variation in WNT9B Increases Relapse Hazard in Multiple Sclerosis
2021
Annals of Neurology
Vandooren J. … Opdenakker G.
Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases
Jun.
2021
Frontiers in Immunology
Vandooren J. and Itoh I.
Alpha-2-Macroglobulin in Inflammation, Immunity and Infections
Dec.
2021
Frontiers in Immunology
Bottemanne P., … Alhouayek M., Muccioli GG.
N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice
Jul.
2021
Neurotherapeutics
Garcia Corales A.V., Haidar M., Bogie J.F.J., Hendriks J.J.A.
Fatty Acid Synthesis in Glial Cells of the CNS
Jul.
2021
International Journal of Molecular Sciences
Peters M., … Hellings N., … Ethirajan A.
PEGylating poly(p-phenylene vinylene)-based bioimaging nanoprobes
Jan.
2021
Journal of colloid and interface science
Ciccone L., Vandooren J., Nencetti S., Orlandini E.
Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's Disease
Jan.
2021
Pharmaceuticals
Tiane A. Schepers M.,… Hellings N., …Vanmierlo T.
DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation
Oct.
2021
Cellular and Molecular Life Sciences
Smets I., … Dubois B., Matthys P., Liston A., Goris A.
Treatment-Induced BAFF Expression and B Cell Biology in Multiple Sclerosis
May
2021
Frontiers in Immunology
Liston A., Humblet-Baron S., Duffy D., Goris A.
Human immune diversity: from evolution to modernity
Dec.
2021
Nature Immunology
Quarta A., Benerman ZW., Ponsaerts P.
Functional consequences of a close encounter between microglia and brain-infiltrating monocytes during CNS pathology and repair
Jul.
2021
Journal of Leukocytes Biology
Wens I., Janssens I., Derdelinckx., Meena M., Willekens B., Cools N.
Made to Measure: Patient-Tailored Treatment of Multiple Sclerosis Using Cell-Based Therapies
Jul.
2021
International Journal of Molecular Sciences

2020

Bogie JFJ., Haidar M., Kooij G., Hendriks JJA.
Fatty acid metabolism in the progression and resolution of CNS disorders
Jan.
2020
Advanced Drug Delivery Reviews
Opdenakker G., El-Asrar AA., Van Damme J.
Remnant Epitopes Generating Autoimmunity: From Model to Useful Paradigm
May
2020
Remnant epitopes generating autoimmunity: from model to useful paradigm
Vanmierlo T., van Horssen J., Hellings N., Broux B.
Editorial: Neuro-Immune Connections to Enable Repair in CNS Disorders
Jul.
2020
Frontiers in Immunology
Martens A., … Voet;s., …Lamkanfi M., … van Loo G.
Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities
Apr.
2020
Nature Immunology
Roggeri A., … Tiane A., Hellings N., … Vanmierlo T.
Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation
Oct.
2020
International Journal of Molecular sciences
Bogie JFJ., Grajchen E., … Broux B., Stinissen P., … Hendriks JJA.
CNS delivery of anti-CD52 antibodies modestly reduces disease severity in an animal model for multiple sclerosis
Aug.
2020
Therapeutic Advances in Chronic Disease
Serifova X., Ugarte-Berzal E., Opdenakker G., Vandooren J.
Homotrimeric MMP-9 is an active hitchhiker on alpha-2-macroglobulin partially escaping protease inhibition and internalization through LRP-1
Aug.
2020
Cellular and Molecular Life Sciences
Wiernicki B., … Vandenabeele P., … Vanden Berghe T.
Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis
Oct.
2020
Cell Death and Disease
Oldoni E., … Van Horebeek L.,… Dubois B., Goris A.
CHIT1 at Diagnosis Reflects Long-Term Multiple Sclerosis Disease Activity
Apr.
2020
Annals of Neurology
Bogie JFJ., Grajchen E., … Hendriks JJA.
Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain
May
2020
Journal of Experimental Medicine
Boon L., Ugarte-Berzal E., Vandooren J., Opdenakker G.
Protease propeptide structures, mechanisms of activation, and functions
Apr.
2020
Critical Reviews in Biochemistry and Molecular Biology
Holgado A. …Afonina IS., Beyaert R.
Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors
Jul.
2020
Frontiers in Immunology
Quarta A., Berneman Z., Ponsaerts P.
Neuroprotective modulation of microglia effector functions following priming with interleukin 4 and 13: current limitations in understanding their mode-of-action
Aug.
2020
Brain, Behavior and Immunity
Costers L., Van Schependom J., ….De Tiège X., Goldman S., D’haeseleer M., D’hooghe MB., …Nagels G.
Spatiotemporal and spectral dynamics of multi-item working memory as revealed by the n-back task using MEG
Jun.
2020
Human Brain Mapping
Grajchen E.,… Hendricks JJA., Bogie JFJ.
CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation
Jul.
2020
Journal of Neuroinflammation
Orefice NS., … Muccioli GG.
miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions
Sep.
2020
eLife
Houben E. ..Vanmierlo T.,..Opdenaker G,....Broux B.,…Hellings N.
Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination
Mar.
2020
Proceedings of the National Academy of Sciences
Derdelinckx J. …Willekens B., Cras P., Benerman ZN., Cools N.
HLA Class II Genotype Does Not Affect the Myelin Responsiveness of Multiple Sclerosis Patients
Dec.
2020
Cells
Jacobs W., …Vanden Berghe T., Jorens PG.
Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID-19): autopsy reveals a ferroptosis signature
Dec.
2020
ESC Heart Failure
Van Horebeek L., Goris A.
Transcript-specific regulation in T-cells in multiple sclerosis susceptibility
Jul.
2020
European Journal of Human Genetics
Perdaens O.,… van Pesch V.
CSF microRNAs discriminate MS activity and share similarity to other neuroinflammatory disorders
Feb.
2020
Neurology

2019

Boon L., Ugarte-Berzal E.,…Vandooren J., …Opdenakker G.
Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B
Mar.
2019
FEBS Journal
Vanden Berghe T. and E. Hoste.
Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids
Jan.
2019
Cell Death & Differentiation
Van Schependom J., …D’hooghe MB., D’haeseleer M., …De Tiège X., Goldman S., …Nagels G.
Altered transient brain dynamics in multiple sclerosis: Treatment or pathology?
Nov.
2019
Human Brain Mapping
Fraussen J., … Somers V.
Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD-CD27- Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients
Sep.
2019
Journal of Immunology
Voet S., Prinz M., van Loo G.
Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology
Jun.
2019
Trends Molecular Medicine
Derdelinckx J…. Cools N.
Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA
Aug.
2019
Journal of Neuroinflammation
Schepers M., Tiane A., … , Piccart E., …Hellings N., …Vanmierlo T.
Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment
Jul.
2019
Frontiers in Immunology
Tiane A., … Hellings N., … Vanmierlo T.
From OPC to Oligodendrocyte: An Epigenetic Journey
Oct.
2019
Cells
Lloyd AF., … des Rieux A., … Miron VE.
Central nervous system regeneration is driven by microglia necroptosis and repopulation
Jun.
2019
Nature Neurosciences
Ugarte-Berzal E., Boon L., …Vandooren J., …Opdenakker G.
MMP-9/Gelatinase B Degrades Immune Complexes in Systemic Lupus Erythematosus
Mar.
2019
Frontiers in Immunology
Voet S., Srinivasan S., Lamkanfi M., van Loo G.
Inflammasomes in neuroinflammatory and neurodegenerative diseases
Jun.
2019
Embo Molecular Medicine
Hassannia B., Vandenabeele P., Vanden Berghe T.
Targeting Ferroptosis to Iron Out Cancer
Jun.
2019
Cancer cell
Quarta A., Le Blon D.,…Ponsaerts P.
Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation
Nov.
2019
Brain, Behavior and Immunity
Rybakin V., … Vandooren J, … Opdenakker G.
Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity
Aug.
2019
Biochemical Journa
Van Horebeek L., Dubois B., Goris A.
Somatic Variants: New Kids on the Block in Human Immunogenetics
Jan.
2019
Trends in Genetics
Van Horebeek L…. Dubois B., Goris A.
A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease
Apr.
2019
Human Molecular Genetics

2018

De Laere M., Berneman ZW., Cools N.
To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis
Mar.
2018
Journal of Neuropathology and Experimental Neurology
De Laere M., Derdelinckx J., …Grajchen E., Hendriks JJA, Bogie JFJ.
The physiology of foamy phagocytes in multiple sclerosis
Nov.
2018
Acta Neuropathologica Communications
Hilven K., … Goris A., Dubois B.
Genetic basis for relapse rate in multiple sclerosis: Association with LRP2 genetic variation
Nov.
2018
Multiple Sclerosis Journal
Lagou V.,… Van Horebeek L.,… Dubois B.,… Goris A.
Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators
Oct.
2018
Cell Reports
Maatveva O., Bogie JFJ., Hendriks JJA., … Kleinewietfeld M.
Western lifestyle and immunopathology of multiple sclerosis
Apr.
2018
Annals of New York Academy of Sciences
Ugarte-Berzal E., … Vandooren J.,… Opdenakker G.
Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis
Oct.
2018
PLoS ONE
Uyttenhove C., … Van Snick J., … van Pesch V.
Prophylactic treatment against GM-CSF, but not IL-17, abolishes relapses in a chronic murine model of multiple sclerosis
Nov.
2018
European Journal of Immunology
Vandooren J. … Opdenakker G.
Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase
May
2018
Frontiers in Immunology
Smets I., … Dubois B., … Goris A., Sawcer S.
Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells
Mar.
2018
Brain
Taj SH., Le Blon D., …Quarta A.,…Ponsaerts P., Hoehn M.
Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke
Jun.
2018
Journal of Neuroinflammation
Voet S., … Lamkanfi M., … van Loo G.
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
May
2018
Nature Communications

2017

De Laere M., … Berneman ZW., Cools N.
Increased Transendothelial Transport of CCL3 Is Insufficient to Drive Immune Cell Transmigration through the Blood-Brain Barrier under Inflammatory Conditions In Vitro
May
2017
Mediators of inflammation
Bogie, JFJ, … Grajchen E., … Hellings N., … Vanmierlo T., Hendriks JJA.
Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes
Mar.
2017
Nature communications/scientific reports
Muls N., …Sindic CJM., van Pesch V.
IL-22, GM-CSF and IL-17 in peripheral CD4+ T cell subpopulations during multiple sclerosis relapses and remission. Impact of corticosteroid therapy
Mar.
2017
PLoS One
Ravanidis S., Bogie JFJ., … Hendriks JJA., Stinissen P., … Hellings N.
Crosstalk with inflammatory macrophages shapes the regulatory properties of Multipotent Adult Progenitor Cells
Jul.
2017
Stem Cells International

2016

Fraussen J., Claes N.,…Stinissen P., … Somers V.
B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses
Dec.
2016
Clinical Immunology
Gonsette R., Debouverie M., Sindic CJM., Ferré JC., Edan G.
Pixantrone: a B-cell-depleting immunosuppressant for multiple sclerosis patients with active disease
Aug.
2016
Multiple Sclerosis
Claes N., Fraussen J., … Hellings N., … Somers V.
Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients
Dec.
2016
Journal of Immunology
Gounko NV., Martens E., Opdenakker G., Rybakin V.
Thymocyte development in the absence of matrix metalloproteinase-9/gelatinase B
Jul.
2016
Nature Scientific Reports
Guglielmetti C., Le Blon D., … Ponsaerts P.
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages
Dec.
2016
Glia
Zielinska KA., … Opdenakker G., … Van den Steen PE.
Endothelial response to Glucocorticoids in inflammatory diseases
Dec.
2016
Frontiers in Immunology
Lee WP., Willekens B., Cras P., …Berneman ZW., Cools N.
Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens
Sep.
2016
Journal of Immunology Research
Dooley J. … Dubois B., Liston A., Goris A.
Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations
May
2016
Neurology, Neuroimmunology & Neuroinflammation
Gerwien H., … Opdenakker G., … Sorokin L.
Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier
Nov.
2016
Science Translational Medicine
Le Blon D., … Berneman ZW., Ponsaerts P.
Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model
Nov.
2016
Journal of Neuroinflammation
Opdenaker G. et al.
Microbiomic and Posttranslational Modifications as Preludes to Autoimmune Diseases
Sep.
2016
Trends Molecular Medicine

2015

Broux B., … Somers V., … Stinissen P., Hellings N.
IL-15 amplifies the pathogenic properties of CD4+CD28- T cells in multiple sclerosis
Mar.
2015
Journal of Immunology
Deckx N., Wens I., … Cools N.
Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis
Oct.
2015
Mediators of inflammation
Ravanidis S., Bogie JFJ., … Stinissen P., … Hellings N.
Neuroinflammatory signals enhance the immunomodulatory and neuroprotective properties of multipotent adult progenitor cells
Sep.
2015
Neuroinflammatory signals enhance the immunomodulatory and neuroprotective properties of multipotent adult progenitor cells
Muls N., … Sindic CJM., van Pesch V.
Regulation of Treg-associated CD39 in multiple sclerosis and effects of corticotherapy during relapse
Oct.
2015
Multiple Sclerosis Journal
Goris A.,…Dubois B., Harbo HF.
Genetic variants are major determinants of CSF antibody levels in multiple sclerosis
Mar.
2015
Brain
Hilven K., Patsoupolos NA., Dubois B., Goris A.
Burden of risk variants correlates with phenotype of multiple sclerosis
Nov.
2015
Multiple Sclerosis Journal