Scientific
publications
In vitro tailoring of regulatory T cells prior to cell therapy
Baeten P., Hellings N., Broux B.
Nov.
2020
Trends in Molecular Medicine
Isolated regulatory T cells (Tregs) are expanded in vitro using anti-CD3/anti-CD28 beads (activation/proliferation) and IL-2 (survival). Polyclonal Tregs are reintroduced into patients safely in graft-versus-host disease (GvHD), transplantation rejection, and type 1 diabetes mellitus (T1DM) clinical trials. The expansion step provides a window of opportunity for in vitro Treg manipulation to boost their function and stability, which are impaired in autoimmunity.
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