VIRUS, ENVIRONMENTAL FACTORS AND LIFESTYLE: GAINING A BETTER UNDERSTANDING OF MS

There is no single cause of multiple sclerosis (MS). The disease develops in cases involving a combination of genetic susceptibility, certain environmental factors and an abnormal immune response. Gaining a better understanding of these interactions is essential if we are to identify the disease mechanisms and, ultimately, break new ground in terms of prevention and treatment.

In the first article in this newsletter, Dr Dries De Wit reflects on the role played by the Epstein-Barr virus. Following decades of suspicions, we now know that an infection by this virus is a vital prerequisite to developing MS in the vast majority of cases, but it is not a cause in and of itself. In fact, while most of us will become infected with this virus at some point in our lives, only a fraction will develop MS. Researchers are now focusing on what makes these people different.

Professor Souraya El Sankari is also examining three other factors being studied within the context of MS: vitamin D, smoking and obesity. Knowledge and the level of evidence vary for each. Whereas the negative effects of smoking are well documented nowadays, studies on obesity and vitamin D continue to shed light on their respective roles with regard to the risk of developing the disease or in disease progression.

These two articles therefore offer complementary perspectives on the factors that may contribute to the development of MS and influence disease progression. While some factors are modifiable, it is essential to remind ourselves that MS is complex and multifactored: an MS diagnosis is never the patient’s fault.

Poised to celebrate its 40^th anniversary, the Belgian Charcot Foundation continues to pursue its original mission set in 1987: to support multiple sclerosis research in Belgium and make breakthroughs available to all. These breakthroughs are the result of the tireless work of researchers and the ongoing generosity of our donors. 

We hope you enjoy reading this newsletter and thank you for your trust and support.

Professor Bénédicte Dubois
Chair of the Belgian Charcot Foundation – Fighting multiple sclerosis