Multiple sclerosis (MS) is a neurological disease of inflammatory origin which causes myelin to be destroyed by the immune system. As well as motor and sensory symptoms, these inflammatory reactions cause many cognitive disturbances, the mechanisms of which remain poorly known. In undertaking this project, we aim to achieve a better understanding of the effects of brain inflammation on the activity of neuronal networks and the synaptic plasticity of the hippocampus using EAE (a MS model in mice). We shall be taking a particular interest in the long-term effects of three major inflammatory actors: NF-kB, microglia and inflammasomes. This study may therefore contribute to the development of new therapeutic strategies to improve cognition and quality of life in patients suffering from neuroinflammatory disorders.