List of scientific publications related to projects funded by the Belgian Charcot Foundation
Disseminating knowledge to shed a light on future options
It is imperative that the results of both basic and clinical research be published to inform the medical and neurological scientific community. Even if some results are negative, it is important to make them known in order to shed light on future options and to trigger creative discussions on the reasons for any failure. This is both necessary and an ethical imperative in the dissemination of knowledge and in the long march towards increasing the effectiveness of treatments for a disease that remains incurable to this day.
Prof. Dr Christian Sindic President
2015-2022
- 2015
Broux B., … Somers V., … Stinissen P., Hellings N. IL-15 amplifies the pathogenic properties of CD4+CD28- T cells in Multiple Sclerosis. Journal of Immunology, 2015, 194:2099-2109
Deckx N., Wens I., … Cools N. Rapid exercise-induced mobilization of dendritic cells is potentially mediated by a Flt3L- and MMP-9-dependent process in Multiple Sclerosis. Mediators of inflammation, 2015, article ID158956
Goris A.,…Dubois B., Harbo HF. Genetics variants are major determinants of CSF antibody levels in multiple sclerosis. Brain, 2015,138:632-643
Hilven K., Patsoupolos NA., Dubois B., Goris A. Burden of risk variants correlates with phenotype of Multiple Sclerosis. Multiple Sclerosis Journal, 2015,21:1670-1680
Muls N., … Sindic CJM., van Pesch V. Regulation of Treg-associated CD39 in multiple sclerosis and effects of vcorticotherapy during relapse. Multiple Sclerosis Journal, 2015,21:1533-1545
Ravanidis S., Bogie JFJ., … Stinissen P., … Hellings N. Neuroinflammatory signals enhance the immunomodulatory and neuroprotective properties of multipotent adult progenitor cells. Stem cell Research & Therapy, 2015, 6:76 (17pp)
- 2016
Claes N., Fraussen J., … Hellings N., … Somers V. Age-associated B cells with proinflammatory characteristics are expanded in a proportion of Multiple Sclerosis Patients. Journal of Immunology, 2016, 197:4576-4583
Dooley J. … Dubois B., Liston A., Goris A. Immunologic profiles of MS treatments reveal shared early B cell alterations. Neurology, Neuroimmunology & Neuroinflammation, 2016, 3:e240
Fraussen J., Claes N.,…Stinissen P., … Somers V. B cells of multiple sclerosis induce autoreactive proinflammatory T cell responses. Clinical Immunology, 2016,173:124-132
Gerwien H., … Opdenakker G., … Sorokin L. Imaging matrix metalloproteinase activity in Multiple Sclerosis as a specific marker of leukocyte penetration of the blood-brain-barrier. Science Translational Medicine;2016, 8:364ra152
Gonsette R., Debouverie M., Sindic CJM., Ferré JC., Edan G. Pixantrone: a B cell depleting immunosuppressant for MS patients with active disease. Multiple Sclerosis, 2016, 22:817-821
Gounko NV., Martens E., Opdenakker G., Rybakin V. Thymocyte development in the absence of matrix metalloproteinase-9/gelatinase B. Nature Scientific Reports, 2016, 6:29852
Guglielmetti C., Le Blon D., … Ponsaerts P. IL-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of Microglia and Macrophages. Glia, 2016,, 64:2181-2200
Le Blon D., … Berneman ZW., Ponsaerts P. Intracerebral transplantation of IL 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model. Journal of Neuroinflammation, 2016, 13:288
Lee WP., Willekens B., Cras P., …Berneman ZW., Cools N. Immunomodulatory effects of 1,25-dihydroxyvitamin D3 on dendritic cells promote induction of T cell hyporesponsiveness to Myelin-derived antigens. Journal of Immunology Research, 2016, article ID5392623
Opdenaker G. et al. Microbiomic and posttranslational modifications as preludes to autoimmune diseases. Trends Molecular Medicine, 2016, 22:746-757
Zielinska KA., … Opdenakker G., … Van den Steen PE. Endothelial response to Glucocorticoids in inflammatory diseases. Frontiers in Immunology, 2016, 7:article 592
- 2017
Bogie, JFJ, … Grajchen E., … Hellings N., … Vanmierlo T., Hendriks JJA. Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes. Nature communications/scientific reports, 2017, 7:44794
De Laere M., … Berneman ZW., Cools N. Increased transendothelial transport of CCL3 is insufficient to drive immune cell transmigration through the BBB under inflammatory conditions in vitro. Mediators of inflammation, 2017, article ID6752756
Muls N., …Sindic CJM., van Pesch V. IL-22, GM-CSF and IL-17 in peripheral CD4+ T cell subpopulations during multiple sclerosis relapses and remission. Impact of corticosteroid therapy. PLoS One, 2017, 12:e0173780
Ravanidis S., Bogie JFJ., … Hendriks JJA., Stinissen P., … Hellings N. Crosstalk with inflammatory macrophages shapes the regulatory properties of Multipotent Adult Progenitor Cells. Stem Cells International, 2017, article 2353240
- 2018
De Laere M., Berneman ZW., Cools N. To the brain and back: migratory paths of dendritic cells in Multiple Sclerosis. Journal of Neuropathology and Experimental Neurology, 2018, 77:178-192
De Laere M., Derdelinckx J., …Grajchen E., Hendriks JJA, Bogie JFJ. The physiology of foamy phagocytes in multiple sclerosis. Acta Neuropathologica Communications, 2018, 6:124
Hilven K., … Goris A., Dubois B. Genetic basis for relapse rate in Multiple Sclerosis: Association with LRP2 genetic variation. Multiple Sclerosis Journal, 2018, 24:1773-1775
Lagou V.,… Van Horebeek L.,… Dubois B.,… Goris A. Genetic architecture of adaptive immune system identifies key immune regulators. Cell Reports, 2018, 25:798-810
Maatveva O., Bogie JFJ., Hendriks JJA., … Kleinewietfeld M. Western lifestyle and immunopathology of Multiple Sclerosis. Annals of New York Academy of Sciences, 2018,1417:71-86
Smets I., … Dubois B., … Goris A., Sawcer S. Multiple Sclerosis risk variants alter expression of co-stimulatory genes in B cells. Brain, 2018, 141:786-796
Taj SH., Le Blon D., …Quarta A.,…Ponsaerts P., Hoehn M. Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke. Journal of Neuroinflammation, 2018,15:174
Ugarte-Berzal E., … Vandooren J.,… Opdenakker G. Gelatinase B/matrix metalloproteinase-9 is a phase specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis. PLoS ONE, 2018,13:e0197944
Uyttenhove C., … Van Snick J., … van Pesch V. Prophylactic treatment against GM-CSF, but not IL-17, abolishes relapses in a chronic murine model of multiple sclerosis. European Journal of Immunology, 2018, 48:1883-1891
Vandooren J. … Opdenakker G. Neutrophils and activated macrophages control mucosal immunity by proteolytic cleavage of antileukoproteinase. Frontiers in Immunology, 2018, 9;article 1154
Voet S., … Lamkanfi M., … van Loo G. A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation. Nature Communications, 2018, 9:2036
- 2019
Boon L., Ugarte-Berzal E.,…Vandooren J., …Opdenakker G. Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B. FEBS Journal, 2019,286:930-945
Derdelinckx J…. Cools N. Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA. Journal of Neuroinflammation, 2019, 16:167
Fraussen J., … Somers V. Phenotypic and immunoglobulin repertoire analysis indicate a common origin of IgD- CD27- double negative (DN) B cells in healthy individuals and multiple sclerosis patients. Journal of Immunology, 2019, 203:1650-1664
Hassannia B., Vandenabeele P., Vanden Berghe T. Targeting ferroptosis to iron out Cancer. Cancer cell, 2019, 35:10:1016/2019.04.002
Lloyd AF., … des Rieux A., … Miron VE. Central nervous system regeneration is driven by microglia necroptosis and repopulation. Nature Neurosciences, 2019, 22:1046-1052
Quarta A., Le Blon D.,…Ponsaerts P. Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarization. Brain, Behavior and Immunity, 2019, 82:406-421
Rybakin V., … Vandooren J, … Opdenakker G. Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity. Biochemical Journal, 2019, 476:2191-2208
Schepers M., Tiane A., … , Piccart E., …Hellings N., …Vanmierlo T. Targeting phosphodiesterases-Towards a tailor-made approach in Multiple Sclerosis Treatment. Frontiers in Immunology, 2019, 10:1727
Tiane A., … Hellings N., … Vanmierlo T. From OPC to oligodendrocyte: an epigenetic journey. Cells, 2019, 8:1236
Ugarte-Berzal E., Boon L., …Vandooren J., …Opdenakker G. MMP-9/Gelatinase B degrades immune complexes in Systemic Lupus Erythematosus. Frontiers in Immunology, 2019,10:508
Vanden Berghe T. and E. Hoste. Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids. Cell Death & Differentiation, 2019, 10:1038
Van Horebeek L., Dubois B., Goris A. Somatic variants : new kids on the block in human immunogenetics. Trends in Genetics, 2019, 35:935-947
Van Horebeek L…. Dubois B., Goris A. A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease. Human Molecular Genetics, 2019, 28:1369-1380
Van Schependom J., …D’hooghe MB., D’haeseleer M., …De Tiège X., Goldman S., …Nagels G. Altered transient brain dynamics in multiple sclerosis: Treatment or pathology? Human Brain Mapping, 2019,40:4789-4800
Voet S., Srinivasan S., Lamkanfi M., van Loo G. Inflammasomes in neuroinflammatory and neurodegenerative diseases. Embo Molecular Medicine, 2019, 11:e10248
Voet S., Prinz M., van Loo G. Microglia in CNS inflammation and Multiple Sclerosis pathology. Trends Molecular Medicine, 2019, 25:112-123
- 2020
Baeten P., Hellings N., Broux B. In vitro tailoring of regulatory T cells prior to cell therapy. Trends in Molecular Medicine, 2020, 26:1059-1060
Bogie JFJ., Grajchen E., … Broux B., Stinissen P., … Hendriks JJA. CNS delivery of anti CD52 antibodies modestly reduces disease severity in an animal model for Multiple Sclerosis. Therapeutic Advances in Chronic Disease, 2020, 11:1-12
Bogie JFJ., Grajchen E., … Hendriks JJA. Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the central nervous system. Journal of Experimental Medicine, 2020,217:e20191660
Bogie JFJ., Haidar M., Kooij G., Hendriks JJA. Fatty acid metabolism in the progression and resolution of CNS disorders. Advanced Drug Delivery Reviews, 2020, 159:198-213
Boon L., Ugarte-Berzal E., Vandooren J., Opdenakker G. Protease propeptide structures, mechanisms of activation, and functions. Critical Reviews in Biochemistry and Molecular Biology, 2020,55:11-165
Costers L., Van Schependom J., ….De Tiège X., Goldman S., D’haeseleer M., D’hooghe MB., …Nagels G. Spatiotemporal and spectral dynamics of multi-item working memory as revealed by the n-back task using MEG. Human Brain Mapping, 2020,41:2431-2446
Derdelinckx J. …Willekens B., Cras P., Benerman ZN., Cools N. HLA Class II genotype does not affect the myelin responsiveness of Multiple Sclerosis patients. Cells, 2020, 9:2703
Grajchen E.,… Hendricks JJA., Bogie JFJ. CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation. Journal of Neuroinflammation, 2020, 17:224 (14pp)
Holgado A. …Afonina IS., Beyaert R. Single-chain soluble receptor fusion proteins as versatile cytokine inhibitors. Frontiers in Immunology, 2020, 11:1422 (11pp)
Houben E. ..Vanmierlo T.,..Opdenaker G,....Broux B.,…Hellings N. Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination. Proceedings of the National Academy of Sciences, 2020, 117:5028-5038
Jacobs W., …Vanden Berghe T., Jorens PG. Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVD-19): autopsy reveals a ferroptosis signature. ESC Heart Failure, 2020, 7:3772-3781
Martens A., … Voet;s., …Lamkanfi M., … van Loo G. Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities. Nature Immunology, 2020,21:381-387
Oldoni E., … Van Horebeek L.,… Dubois B., Goris A. CHIT1 at diagnosis reflects long-term Multiple Sclerosis Disease activity. Annals of Neurology, 2020, 87:633-645
Opdenakker G., El-Asrar AA., Van Damme J. Remnant epitopes generating autoimmunity: from model to useful paradigm. Trends in Immunology, 2020,41:367-278
Orefice NS., … Muccioli GG. miRNA profiles is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions. eLife, 2020, 9:e56916
Perdaens O.,… van Pesch V. CSF microRNAs discriminate MS activity and share similarity to other neuroinflammatory disorders. Neurology, Neuroimmunolology & Neuroinflammation, 2020, 7:e673
Quarta A., Berneman Z., Ponsaerts P. Neuroprotective modulation of microglia effector functions following priming with interleukin 4 and 13: current limitations in understanding their mode-of-action. Brain, Behavior and Immunity, 2020, 88:856-866
Roggeri A., … Tiane A., Hellings N., … Vanmierlo T. Sphingosine-1-phosphate receptor modulators and oligodendroglial cells: beyond immunomodulation. International Journal of Molecular sciences, 2020, 21:7537
Serifova X., Ugarte-Berzal E., Opdenakker G., Vandooren J. Homotrimeric MMP-9 is an active hitchhiker on alpha-2-macroglobulin partially escaping protease inhibition and internalization through LRP-1. Cellular and Molecular Life Sciences, 2020,77:3013-3026
Van Horebeek L., Goris A. Transcript-specific regulation in T-cells in Multiple Sclerosis susceptibility. European Journal of Human Genetics, 2020, 28:849-850
Vanmierlo T., van Horssen J., Hellings N., Broux B. Editorial: Neuro-immune connections to enable repair in CNS disorders. Frontiers in Immunology, 2020, 11:1425
Wiernicki B., … Vandenabeele P., … Vanden Berghe T. Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis. Cell Death and Disease, 2020, 11:922
- 2021
Cauwels A. et al. Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE. Nature.communications/scientific reports, 2021, 11:21575
Ciccone L., Vandooren J., Nencetti S., Orlandini E. Natural marine and terrestrial componds as modulators of Matrix Mettaloproteinases-2 (MMP-2) and MMP-9 in Alzheimers’disease. Pharmaceuticals, 2021,14:86
Costers L., Van Schependom J., … De Tiège X., Goldman S., D’haeseleer M., D’hooghe MB., … Nagels G. The role of hippocampal theta oscillations in working memory impairment in Multiple Sclerosis. Human Brain Mapping, 2021, 42:1376-1390
Garcia Corales A.V., Haidar M., Bogie J.F.J., Hendriks J.J.A. Fatty acid synthesis in glial cells of the CNS. International Journal of Molecular Sciences, 2021,22:8159
Gratpain, V., … Muccioli GG., van Pesch V., des Rieux A. Extracellular vesicles for the treatment of central nervous system diseases. Advanced Drug Delivery Reviews, 2021, 174:535-552
Hassannia B., Van Coillie S., Vanden Berghe T. Ferroptosis : biological rust of lipid membranes. Antioxidants & Redox Signaling, 2021, 35:487-509
Liston A., Humblet-Baron S., Duffy D., Goris A. Human immune diversity: from evolution to modernity. Nature Immunology, 2021, 22:1479-1489
Meena M., … De Laere M.,… Benerman Z., Cools N. Transmigration across a steady-state Blood-Brain-Barrier induces activation of circulating dendritic cells partly mediated by actin cytoskeletal reorganization. Membranes, 2021, 11:700
Oltean T., … Vanden Berghe T., … Vandenabeele P. Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL. Cell Death and Disease, 2021, 12:471
Peters M., … Hellings N., … Ethirajan A. PEGylating poly(p-phenylene vinylene)-based bioimaging nanoprobes. Journal of colloid and interface science, 2021, 581:566-575
Quarta A., Benerman ZW., Ponsaerts P. Functional consequences of a close encounter between microglia and brain-infiltrating monocytes during CNS pathology and repair. Journal of Leukocytes Biology, 2021, 110:89-106
Quarta A…Le Blon D.,…Ponsaerts P. Murine induced pluripotent stem cell-derived neuroimmune cell culture models emphasize opposite immune-effector functions of interleukine 13-primed microglia and macrophages in terms of neuroimmune toxicity. Glia, 2021, 69:326-345
Smets I., … Dubois B., Matthys P., Liston A., Goris A. Treatment-induced BAFF expression and B cell biology in Multiple Sclerosis. Frontiers in Immunology, 2021, 12:676619
Smets I., Goris A., … Dubois B. Quantitative MRI phenotypes capture biological heterogeneity in Multiple Sclerosis patients. Nature Communications/ Scientific report, 2021,11:1573
Tiane A. Schepers M.,… Hellings N., …Vanmierlo T. DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation. Cellular and Molecular Life Sciences, 2021, 78:6631-6644
Vandebergh M., … Dubois B., Goris A. Genetic variation in WNT9B increases relapse hazard in Multiple Sclerosis. Annals of Neurology, 2021, 89:884-894
Vandooren J. … Opdenakker G. Internal disulfide bonding and glycosylation of interleukin-7 protect against proteolytic inactivation by neutrophil metalloproteinases and serine proteases. Frontiers in Immunology, 2021, 12:article 701739
Vandooren J. and Itoh I. Alpha-2-macroglobulin in inflammation, immunity and infections. Frontiers in Immunology, 2021,12:803244
Van Schependom J., … D’hooghe MB., D’haeseleer M., … De Tiège X., Goldman S., …Nagels G. Increased brain atrophy and lesion load is associated with stronger lower alpha MEG power in multiple sclerosis patients. Neuroimage: Clinical, 2021, 30:102632
Wens I., Janssens I., Derdelinckx., Meena M., Willekens B., Cools N. Made to measure: patient-tailored treatment of Multiple Sclerosis using cell-based therapies. International Journal of Molecular Sciences, 2021, 22:7536
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2022
Baeten P., Van Zeebroeck L., Kleinewietfeld M., Hellings N., Broux B . Improving the efficacy of regulatory T cell therapy. Clinical Reviews in Allergy & Immunology, 2022,62:363-381
Beliën J., Goris A., Matthys P. Natural killer cells in Multiple Sclerosis: entering the stage. Frontiers in Immunology, 2022,13:869447
Brocke S., Epstein P.M., Nelson R., Vanmierlo T. Editorial: Cyclic nucleotide phosphodiesterases (PDEs) in immune regulation and inflammation. Frontiers in Pharmacology, 2022,13:950480
Goris A.,Vandebergh M.,McCauley JL.,Saarela J., Cotsapas C. Genetics of multiple sclerosis: lessons from polygenicity. Lancet Neurology,2022,21:830-842
Guns J., Vanherle S., Hendriks JJA., Bogie JFJ. Protein lipidation by palmitate controls macrophage function. Cells, 2022, 11:565
Haidar, M., Loix M., …Bogie JFJ., Hendriks, JJA. Targeting lipophagy in macrophages improves repair in Multiple Sclerosis. Autophagy, 2022,18:2697-2710
Hassanabadi NS., Broux B., Marinivic S., Gotthardt D. Innate lymphoid cells-Neglected players in Multiple Sclerosis. Frontiers in Immunology,2022,13:909275
Hermans D., Houben E., Baeten P., …Fraussen J.,…Hellings N., Broux B. Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity. Acta Neuropathologica, 2022,144:259-281
Hoeks C., Duran G., Hellings N., Broux B. When helpers go above and beyond development and characterization of cytotoxic CD4+ T cells. Frontiers in Immunology, 2022,13:951900
Janssens I., ..., Van den Bos J., ..., Berneman Z.N., Wens I., Cools N. Engineering of regulatory cells by means of mRNA electroporation in a GMP-compliant manner. Cytotherapy, 2022,24:659-672
Labrak Y., … Muccioli GG., des Rieux A. Impact of anti-PDGFR alpha antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells. International Journal of Pharmaceutics, 2022, 618:121623.
Meena M., … Berneman Z., Watts R., Cools N. A microfluidic in vitro three-dimensional dynamic model of the Blood-Brain-Barrier to study the transmigration of immune cells. Brain Sciences, 2022,12:1293
Van Breedam E., Berneman ZW., … Vanden Berghe T., … Ponsaerts P. Luminescent human IPSC-derived neurospheroids enable modelling of neurotoxicity after oxygen-glucose deprivation. Neurotherapeutics, 2022, doi.org/10.1007/s13311
Van Broeckhoven J., …Ponsaerts P., et al. Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury. Journal of Neuroinflammation, 2022,19:102