The molecular mechanisms regulating the differentiation of the precursors of myelinating cells in the central nervous system into oligodendrocytes are a major avenue of research in understanding the disease. In fact, these precursors’ capacity for differentiation is inhibited as the disease progresses, and this restricts the remyelination capacity by mature oligodendrocytes. Our project aims to study the role of one particular molecule, Elongator, in regulating the differentiation of precursors into myelinating cells. We suspect that Elongator promotes demyelination by inducing the de-differentiation of oligodendrocytes, that is by maintaining these cells in an immature state. We plan to check this hypothesis by working with oligodendrocytes deprived of this molecule, and to examine their myelinating and proliferative properties using “in vivo” and “in vitro” approaches.