In the presence of oxygen, unprotected iron rusts. A similar process in our body can lead to iron-dependent cell death, a kind of biological rust, which can lead to damage or degeneration. This new form of cell death is called ferroptosis. Small chemical compounds that block biological rust appear to have a protective effect against neurodegeneration. We have developed and patented a new generation of chemical compounds that prove to be superior in many aspects compared to the original compounds. Because we already have experimental evidence that biological rust worsens the progression of multiple sclerosis (MS), we want to investigate to what extent our chemical compounds can improve the disease profile in an experimental model of relapse-remitting MS.
Our aim: Therapeutic exploration of novel inhibitors of biological rust in multiple sclerosis.