This project aims to identify the mechanisms underlying cognitive impairments associated to multiple sclerosis by using a murine model of central nervous system inflammation.
Nearly half of Multiple Sclerosis (MS) patients suffer from impaired cognitive function. These cognitive problems concern several aspects such as long-term memory, attention, efficiency and speed of information processing. Combined with fatigue, these symptoms have a significant negative impact on the quality of life of patients. The mechanisms underlying these symptoms are not yet well known, but scientific findings point to a role for inflammatory processes taking place in the brain. Using an animal model, this project will enable us to better understand these mechanisms but also to propose new therapeutic targets for the treatment of cognitive disorders.