Our study will provide new fundamental knowledge helping us to better understand the molecular mechanisms that control autoimmune inflammation in the brain, especially in the context of MS, with the ultimate goal to contribute to the development of new and better therapies to treat patients suffering from the disease.

Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system. Macrophages derived from infiltrating monocytes and resident microglia contribute to the inflammatory reactions in MS. In this project, we will focus on the role and importance of the metabolite itaconate as an anti-inflammatory protective mechanism induced by activated macrophages and microglia during MS. By studying the molecular mechanisms behind macrophage and microglia activation, we hope to contribute to a better knowledge on MS which may help in the development of better therapies to treat the disease.