Although there is a lot of research for new drugs to treat MS, there is a lack of appropriate systems that would efficiently deliver new treatments to the central nervous system. Among the new research avenues to fight against MS, microRNAs (miRNA) have recently raised a lot of interest. Prof. van Pesch’s team identified 2 miRNAs that could have a therapeutic potential. The problem with miRNA is that they are very fragile and cannot enter cells alone. Vesicles produced by cells, called extracellular vesicles, are quite interesting as they can cross barriers and can be loaded with miRNA. So here, our main objective is to use extracellular vesicles as a new delivery system for therapeutic miRNA against MS.