There is a high need for novel, more effective therapies for progressive forms of MS. Progressive MS is linked to the presence of chronic active lesions in the central nervous system (CNS). These lesions are characterized by immune cells that promote inflammation and tissue degradation, and prevent CNS repair. Our recent data show that enzymes of fatty acid synthesis drive the induction of these lesion promoting immune cells. In this project, we determine if targeting these enzymes can skew phagocytes in MS towards a reparative phenotype. Obtained results will lead to increased insight into lesion progression in MS and the identification of new therapeutic targets for the development of improved treatments for progressive MS.