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Prof. Tim Vanmierlo, Prof Daniel van den Hove and Drs. Assa Tiane

Forever young – the epigenetic clock of OPCs


€ 43,500 / 2 years

During the progressive phase of MS, oligodendrocyte precursor cells (OPCs) fail to fully mature into myelin producing cells that are required for repair of the damaged nerve cells. Interestingly, it has been described in literature that this maturation process of OPCs is also hampered upon ageing in healthy individuals. We have previously shown that specific changes on the DNA of OPCs can influence their maturation process. In this project, we aim to investigate whether OPCs from MS patients undergo premature ageing and resemble aged OPCs based on the changes on top of their DNA. By altering these DNA changes we aim to rejuvenate aged OPCs so that they can mature again into myelin producing cells in order to restore the myelin around the damaged nerve cells.