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Prof. Vincent van Pesch, Dr. M. Alhouayek, Prof. G. Muccioli and Dr. L. D’auria

Lipids and microRNAs from Extracellular Vesicles in Multiple Sclerosis: deciphering pathophysiology to discover novel therapeutic pathways


€60,000/ 2 years

Our aim: a functional study of lipid mediators and microRNAs from the cerebrospinal fluid in the pathophysiology of multiple sclerosis in order to identify innovative therapeutic targets

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). To treat the disease, it is essential to identify novel molecules involved in MS pathology, trafficking within the cerebrospinal fluid, a window on CNS diseases. Extracellular vesicles (EVs) circulate in all body fluids and can regulate cell-to-cell communication in diseases, including MS, by carrying many poorly investigated molecules, among which lipid mediators and microRNAs. We aim to isolate EVs from the CSF of MS patients. We will characterize their composition in microRNAs and lipids. We will then assess the effects of identified microRNAs and lipids on the immune response and on neuroinflammation. This will allow the discovery of new therapeutic targets.